HIV-1 vaccine design through minimizing envelope metastability

Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens

The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome.

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use

PURPOSE OF REVIEW To provide an update on the latest developments in the field of HIV-1 antibody-based soluble envelope glycoprotein (Env) trimer design for vaccine use. RECENT FINDINGS The development of soluble native-like HIV-1 Env trimer immunogens has moved the field of antibody-based vaccine design forward dramatically over the past few years with refinement of various stabilizing appro...

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and neutralization. Despite advances in trimer design, the roots of Env trimer metastability remain elusive. Here we investigate the contribution of two Env regions to metastability. First, we computationally redesign a largely disordered bend in heptad region 1 (HR1) of SOSIP trimers that connects the long, ...

HIV Envelope-Specific Antibody and Vaccine Efficacy

Vaccine induced HIV - 1 envelope gp 120 Constant Region 1 - specific Antibodies

24 Mucosal epithelial cell surface galactosylceramide (Galcer) has been postulated to be a receptor 25 for HIV-1 envelope (Env) interacting with mucosal epithelial cells. Disruption of HIV-1 Env 26 interaction with such alternate receptors could be one strategy to prevent HIV-1 entry through 27 the mucosal barrier. To study antibody modulation of HIV-1 Env-Galcer interactions, we have 28 used G...